Locus Information
Locus Info
Protein Info
GO Info
Orthologs
Standard Name
IRA2 Systematic Name
YOL081W Alias
CCS1, GLC4 Strain
S288c Description
GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; IRA2 has a paralog, IRA1, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis External sources
Open in SGD
Open in KEGG
Gene Sequence
Download FASTA Hide Seq
>IRA2 YOL081W
ATGTCCCAGCCCACTAAGAATAAGAAGAAAGAACACGGGACCGATTCCAAGTCATCCCGC
ATGACTCGGACGTTGGTTAATCATATTCTTTTTGAAAGAATTCTCCCGATCCTTCCGGTG
GAGTCTAATCTAAGTACCTATTCGGAAGTGGAAGAGTATTCCTCATTCATTTCATGCAGA
TCTGTGCTCATTAACGTTACCGTTTCCCGAGATGCAAATGCTATGGTGGAAGGCACCTTG
GAGTTGATAGAATCGCTTCTTCAAGGGCACGAAATCATTTCAGATAAGGGTAGCAGTGAC
GTTATTGAATCAATACTGATTATACTAAGATTGTTAAGTGATGCGCTAGAGTATAATTGG
CAAAATCAAGAAAGCCTTCATTACAACGACATTTCGACTCACGTAGAACATGACCAAGAA
CAGAAGTACAGACCAAAGCTTAACAGTATTCTGCCCGACTACTCGTCGACTCATTCCAAT
GGCAACAAACACTTTTTCCACCAGAGCAAACCTCAGGCACTGATACCGGAACTGGCATCG
AAATTGCTTGAGAGTTGCGCGAAGTTGAAGTTCAATACAAGAACTTTGCAAATTTTACAA
AATATGATCAGTCATGTTCATGGAAACATTCTAACGACTTTGAGTTCCTCGATTCTTCCC
CGCCACAAATCCTATCTGACAAGGCACAACCATCCTTCTCATTGTAAAATGATTGACTCT
ACTCTAGGCCATATTCTCCGATTTGTAGCGGCTTCCAATCCGTCCGAGTATTTTGAATTT
ATCAGAAAGAGTGTGCAAGTGCCCGTAACACAGACACACACGCATTCACACTCCCATTCA
CACTCTTTGCCATCTTCCGTTTATAACAGCATAGTGCCCCACTTTGATCTTTTCAGCTTC
ATCTATTTAAGCAAGCATAATTTTAAGAAATACTTGGAACTCATCAAAAACTTATCGGTG
ACGTTAAGGAAAACGATTTATCATTGCCTACTTTTGCATTACAGCGCCAAAGCAATAATG
TTTTGGATAATGGCTAGGCCTGCGGAATATTATGAACTCTTCAACTTATTAAAAGATAAT
AACAATGAACACTCGAAATCCTTAAACACGTTAAACCATACACTTTTCGAGGAGATCCAT
TCGACTTTTAATGTGAATAGCATGATAACCACCAATCAAAATGCTCATCAAGGCTCATCT
TCCCCTTCGTCCTCCTCGCCATCGTCACCACCTAGCTCATCATCATCGGATAACAACAAT
CAAAACATAATAGCAAAATCCTTAAGTCGTCAGCTTTCTCACCACCAGTCATACATTCAA
CAGCAGTCTGAAAGAAAACTACATTCTTCATGGACTACAAACTCTCAATCCTCTACTTCA
CTGTCATCTTCAACGTCTAATTCAACAACAACTGATTTCTCTACTCACACTCAACCAGGA
GAATATGACCCTTCCTTACCAGATACTCCCACGATGTCTAACATCACTATTAGTGCATCT
TCATTATTATCTCAAACTCCAACTCCAACAACACAATTGCAACAGCGGTTGAACTCAGCA
GCTGCAGCCGCCGCCGCAGCTGCTTCACCATCGAATTCCACCCCAACTGGATACACAGCA
GAGCAACAAAGTCGCGCTTCATACGATGCACACAAAACTGGCCATACTGGTAAGGATTAT
GACGAACATTTTTTGTCTGTCACTCGTTTGGATAATGTTTTGGAGTTATACACGCACTTT
GATGATACTGAGGTACTACCACACACATCCGTACTGAAGTTTTTAACTACTTTGACAATG
TTCGATATTGACCTTTTTAATGAATTAAACGCTACATCATTCAAATATATTCCTGATTGT
ACTATGCATCGTCCAAAAGAAAGAACAAGTTCTTTCAATAATACTGCACACGAGACAGGT
TCCGAAAAGACTTCGGGTATAAAACATATTACACAAGGCTTAAAGAAATTAACTTCTTTA
CCTTCCTCAACCAAAAAAACTGTAAAATTTGTGAAGATGTTGCTAAGAAATTTAAATGGG
AATCAAGCTGTATCAGATGTTGCCCTCTTAGATACAATGAGGGCCTTACTATCATTCTTT
ACAATGACTTCTGCGGTCTTTCTCGTGGATAGAAACTTACCCTCAGTACTTTTTGCCAAG
AGACTCATCCCCATAATGGGGACAAATTTAAGCGTCGGTCAAGACTGGAATTCAAAAATA
AATAACAGTTTGATGGTTTGTTTGAAAAAAAACTCCACCACGTTTGTTCAATTACAATTA
ATATTCTTCTCTTCAGCTATTCAATTCGATCATGAATTATTACTGGCACGTCTGAGCATC
GATACAATGGCCAACAATTTAAACATGCAGAAGCTATGCCTTTATACTGAAGGATTCAGG
ATATTCTTCGACATACCAAGTAAGAAGGAATTGCGGAAGGCAATTGCGGTTAAAATTTCT
AAATTTTTCAAAACATTATTCTCCATTATAGCAGATATTCTTTTACAAGAATTTCCGTAT
TTTGATGAGCAAATCACCGACATAGTTGCTTCCATTCTTGACGGTACAATTATCAATGAG
TATGGTACGAAGAAACATTTCAAGGGGAGCTCACCCTCTTTATGTTCGACAACCCGGTCA
AGATCAGGATCTACATCTCAAAGTTCAATGACACCAGTTTCTCCGCTGGGACTGGATACT
GATATATGTCCAATGAACACCCTGTCTTTAGTTGGTTCAAGTACTTCAAGAAATTCTGAC
AACGTTAATTCATTAAACAGTTCACCAAAGAACTTGTCTTCTGATCCATACTTGTCACAT
CTTGTGGCCCCAAGAGCGCGTCATGCTTTAGGTGGGCCATCTAGTATTATAAGGAATAAA
ATACCGACTACATTGACTTCACCTCCAGGAACGGAAAAATCTTCACCAGTACAACGTCCG
CAAACGGAAAGCATCAGTGCCACACCAATGGCCATAACAAATTCTACTCCATTATCGTCG
GCAGCATTCGGAATTCGATCGCCTTTGCAGAAAATAAGAACGAGGCGTTATTCCGATGAA
AGTTTAGGAAAATTCATGAAATCAACAAATAATTACATTCAAGAACATTTGATACCAAAA
GATTTGAATGAAGCAACTCTTCAAGATGCTAGAAGAATAATGATTAATATTTTCAGTATT
TTTAAGAGACCGAATAGTTACTTCATCATTCCTCACAATATAAACTCGAATTTACAATGG
GTTTCGCAGGATTTTAGAAATATTATGAAACCGATTTTCGTCGCCATCGTAAGTCCGGAT
GTAGATTTACAGAATACTGCTCAATCATTCATGGATACCTTATTATCGAATGTTATTACT
TATGGTGAATCAGATGAGAATATCAGTATTGAAGGGTATCATCTTCTTTGCAGTTACACT
GTAACATTATTTGCAATGGGCCTTTTCGATTTGAAAATTAATAATGAAAAGCGTCAAATT
CTCTTGGATATAACTGTCAAGTTTATGAAGGTTAGATCACATTTAGCAGGGATCGCGGAG
GCCTCACACCACATGGAATACATAAGTGATTCTGAAAAACTCACCTTTCCGCTGATTATG
GGGACTGTTGGTAGGGCCCTATTTGTTTCATTATACTCTAGTCAACAAAAAATTGAAAAG
ACTTTAAAGATTGCTTACACAGAGTATCTTTCTGCAATCAATTTTCATGAGAGGAATATT
GATGATGCTGATAAAACTTGGGTTCATAATATTGAGTTTGTAGAAGCGATGTGTCATGAC
AACTACACAACTTCTGGTTCAATTGCTTTCCAAAGGAGGACAAGAAATAATATTTTACGA
TTTGCTACTATTCCTAACGCTATCTTACTTGATTCTATGAGGATGATCTATAAGAAGTGG
CATACTTACACACACAGTAAAAGTTTAGAAAAACAAGAACGGAACGACTTCAGAAATTTC
GCGGGTATTTTAGCCTCTTTGTCGGGTATCCTATTCATCAATAAAAAGATATTGCAAGAA
ATGTATCCATACCTACTCGACACCGTTTCAGAATTGAAAAAAAATATAGACTCTTTTATC
TCAAAACAATGCCAATGGTTAAACTATCCGGATTTATTAACGAGAGAAAATTCAAGAGAT
ATTCTAAGTGTAGAACTGCATCCTTTGTCTTTTAACTTACTTTTTAATAATTTGAGGCTC
AAGTTAAAAGAACTTGCTTGTTCAGACTTATCAATACCAGAAAATGAAAGTTCCTATGTT
TTATTAGAACAAATAATCAAAATGCTGCGGACAATCCTAGGTCGTGATGATGACAATTAT
GTAATGATGCTTTTTTCCACAGAGATTGTAGATCTTATTGATTTATTGACAGATGAAATA
AAAAAAATACCAGCCTATTGTCCAAAATATCTCAAGGCAATTATTCAAATGACCAAAATG
TTCAGTGCCTTGCAGCACTCAGAGGTTAATTTAGGTGTCAAAAATCATTTTCACGTTAAA
AATAAATGGTTGAGGCAAATCACTGATTGGTTTCAAGTGAGTATTGCGAGAGAGTACGAT
TTCGAAAACTTGTCAAAACCTCTAAAAGAAATGGATTTGGTAAAAAGAGACATGGATATT
CTATACATAGATACGGCAATCGAAGCTTCAACCGCTATTGCGTACCTCACGAGACATACT
TTCTTAGAGATTCCACCTGCCGCGTCAGATCCCGAACTATCTCGATCTAGGTCTGTGATA
TTTGGGTTTTATTTCAACATCTTAATGAAAGGCCTTGAAAAAAGTAGTGATCGTGACAAT
TACCCAGTATTCTTGAGGCACAAAATGAGTGTCCTCAACGACAATGTAATACTTTCATTA
ACAAATCTTTCAAACACCAATGTTGATGCGAGTTTGCAGTTCACCTTACCGATGGGCTAT
TCCGGAAATCGAAACATTAGGAATGCATTTTTGGAGGTCTTCATTAATATCGTTACGAAC
TATCGGACATACACGGCTAAAACTGACCTTGGAAAATTAGAGGCAGCAGACAAATTTTTG
CGATATACGATTGAACATCCCCAGCTATCGTCCTTTGGAGCAGCGGTTTGTCCCGCTAGC
GATATTGATGCTTATGCTGCTGGCTTAATAAATGCATTTGAAACGAGGAATGCCACCCAC
ATTGTAGTGGCACAGTTGATTAAAAATGAAATTGAAAAATCTTCCAGACCTACGGATATC
CTTAGAAGAAATAGCTGTGCTACGAGATCATTATCTATGCTAGCCAGGTCCAAGGGTAAC
GAATATTTGATTCGCACTTTGCAACCATTACTAAAAAAAATTATCCAGAACAGAGATTTT
TTTGAAATTGAGAAACTAAAACCGGAAGATTCAGATGCTGAACGTCAAATAGAGCTCTTC
GTTAAATACATGAATGAATTATTGGAATCCATATCCAACTCCGTATCTTATTTTCCCCCT
CCTTTATTTTATATTTGCCAAAACATTTATAAAGTTGCGTGTGAAAAATTTCCGGATCAC
GCAATTATCGCCGCTGGGTCTTTCGTGTTTTTACGGTTTTTTTGTCCTGCTTTAGTCAGC
CCTGATTCTGAAAATATCATAGATATTTCTCACTTGAGCGAAAAGCGTACCTTCATCAGC
TTGGCTAAAGTTATCCAAAATATTGCCAATGGCTCAGAAAATTTCTCCAGATGGCCAGCT
TTGTGTTCCCAAAAGGATTTTCTTAAGGAATGTAGCGATAGAATTTTCAGATTCCTAGCT
GAACTTTGTAGAACAGATCGCACGATAGACATCCAAGTGAGAACAGACCCAACGCCAATT
GCATTTGACTATCAATTCCTTCATTCCTTTGTTTACCTTTACGGTCTTGAGGTGAGAAGG
AATGTGCTAAATGAAGCAAAACATGATGATGGTGACATTGATGGTGACGATTTCTATAAG
ACCACATTTTTACTTATTGATGATGTTCTTGGCCAATTAGGCCAACCTAAAATGGAATTT
TCCAATGAAATACCAATATACATAAGAGAACATATGGACGACTATCCGGAACTGTATGAG
TTCATGAATAGGCACGCGTTCAGAAACATTGAGACTTCAACAGCGTACAGCCCAAGCGTT
CACGAGTCCACCTCAAGTGAAGGCATTCCAATTATTACGTTAACAATGTCAAATTTCTCA
GACAGACATGTGGACATTGATACAGTTGCTTACAAGTTCTTGCAAATTTATGCTCGAATC
TGGACCACCAAACACTGTTTAATAATCGACTGTACAGAATTTGACGAGGGAGGGCTTGAT
ATGAGGAAATTTATTTCTTTGGTTATGGGACTATTACCAGAAGTTGCACCCAAAAATTGT
ATAGGCTGTTACTACTTTAACGTAAACGAGACATTTATGGATAATTATGGAAAATGTTTG
GACAAAGACAACGTATATGTTTCCTCGAAAATTCCTCATTATTTCATTAATAGTAACTCT
GATGAAGGACTTATGAAATCTGTGGGTATAACTGGACAAGGGTTGAAGGTTCTGCAAGAT
ATTCGTGTCTCTCTGCATGATATCACGCTTTATGACGAAAAAAGAAATAGATTTACGCCG
GTATCGTTGAAAATAGGCGATATTTACTTTCAAGTCTTGCATGAAACTCCTAGGCAATAT
AAAATAAGGGACATGGGTACTTTATTCGACGTAAAATTCAATGATGTCTACGAAATTAGC
CGAATATTTGAAGTACATGTTTCGTCAATAACTGGAGTGGCAGCTGAATTTACAGTAACT
TTTCAGGACGAGAGAAGGTTGATTTTTAGTAGTCCGAAATACCTTGAAATTGTGAAGATG
TTCTATTACGCACAGATCCGGTTAGAAAGTGAATATGAAATGGATAATAATTCGAGTACC
TCCTCCCCAAATTCAAACAACAAGGACAAACAGCAGAAAGAGAGAACAAAACTATTGTGC
CACCTACTGTTAGTATCTCTTATTGGTCTGTTTGATGAGAGTAAAAAAATGAAAAACAGT
TCGTATAACCTAATAGCTGCCACTGAGGCGTCATTTGGTTTGAACTTTGGCTCCCATTTT
CATCGCTCTCCCGAGGTGTACGTCCCCGAAGATACTACAACATTTTTAGGTGTTATTGGA
AAGTCTCTTGCAGAGTCTAATCCAGAACTCACAGCCTATATGTTTATCTATGTTTTGGAG
GCATTGAAGAACAACGTAATTCCTCACGTTTACATCCCTCATACCATTTGCGGTTTGTCT
TATTGGATCCCTAATTTATACCAACATGTGTATTTGGCTGATGATGAAGAAGGCCCCGAA
AACATATCTCACATTTTCCGAATTCTTATCAGGCTCTCTGTGAGAGAGACTGACTTTAAA
GCCGTATACATGCAATATGTTTGGTTGCTACTTTTAGATGATGGCCGCTTAACTGACATT
ATCGTTGATGAAGTTATTAATCATGCGTTAGAAAGAGACTCCGAAAACCGCGATTGGAAG
AAAACAATATCGTTACTGACTGTCCTACCCACTACTGAGGTTGCTAATAATATTATTCAA
AAAATATTGGCAAAAATTAGATCATTTTTACCGTCATTGAAGTTAGAAGCTATGACCCAA
AGTTGGTCTGAACTAACAATATTAGTTAAGATAAGCATCCACGTTTTTTTTGAAACTTCT
TTGCTGGTACAGATGTACTTACCAGAGATCCTGTTTATCGTATCCTTATTAATTGATGTT
GGTCCAAGGGAACTCAGATCATCACTACACCAGCTATTAATGAATGTATGCCATTCCTTG
GCTATTAACTCAGCTTTACCACAAGATCATAGAAATAATCTAGATGAAATAAGTGATATA
TTTGCACATCAAAAGGTGAAGTTTATGTTTGGGTTCAGCGAGGACAAAGGACGAATTTTA
CAGATTTTTAGCGCTTCTTCTTTTGCAAGCAAGTTTAATATTCTGGATTTCTTCATCAAT
AATATATTATTGCTGATGGAATATTCTTCAACGTACGAAGCAAACGTGTGGAAGACAAGA
TACAAGAAATATGTCTTGGAATCTGTGTTTACAAGTAATTCTTTTCTTTCGGCACGTTCA
ATCATGATTGTTGGTATAATGGGTAAATCTTACATAACTGAAGGGTTATGCAAGGCTATG
TTAATTGAAACCATGAAAGTTATCGCCGAACCAAAGATTACTGACGAGCATCTTTTCTTA
GCCATATCTCATATTTTTACTTATTCCAAAATTGTTGAAGGTTTGGATCCCAACCTTGAC
TTAATGAAGCACTTATTTTGGTTTTCAACACTCTTCCTTGAATCACGTCACCCGATAATT
TTTGAGGGTGCCCTTCTCTTTGTGTCAAACTGTATAAGGCGCCTATACATGGCCCAGTTT
GAAAATGAAAGCGAAACATCATTGATAAGTACTTTACTTAAGGGGAGAAAGTTTGCTCAT
ACCTTTTTAAGCAAGATAGAGAATCTTAGTGGTATTGTTTGGAATGAAGATAATTTTACA
CACATTCTGATTTTCATCATTAATAAAGGACTATCCAATCCTTTCATTAAGAGTACGGCT
TTTGATTTCTTGAAGATGATGTTTAGAAACTCCTACTTTGAGCATCAAATCAATCAGAAA
TCTGATCATTATTTGTGCTATATGTTCCTATTGTATTTTGTTTTAAACTGCAATCAATTT
GAGGAACTTTTAGGTGACGTTGATTTTGAAGGAGAAATGGTTAACATTGAAAACAAGAAC
ACCATTCCTAAAATTTTGTTAGAGTGGTTGAGTTCGGATAACGAAAATGCAAACATTACC
CTCTATCAAGGTGCGATACTGTTCAAATGTTCAGTTACGGATGAACCAAGTAGATTTAGG
TTTGCGTTGATTATTAGGCATCTATTGACAAAGAAACCCATTTGTGCATTGCGTTTTTAC
AGTGTTATTCGTAACGAAATAAGAAAAATATCAGCATTTGAGCAAAATTCGGATTGTGTT
CCACTTGCTTTCGATATTTTAAACTTATTAGTGACGCATTCAGAGTCTAATTCGTTAGAA
AAACTTCACGAAGAATCCATTGAACGTCTAACCAAAAGAGGTTTATCGATTGTGACTTCT
TCTGGTATATTTGCGAAGAACTCCGACATGATGATACCTTTAGATGTAAAACCTGAAGAT
ATCTATGAACGTAAGAGAATAATGACAATGATTTTATCAAGGATGTCATGTTCTGCTTAG Promoter Sequence
Download FASTA
>IRA2 YOL081W
CGAAACTCTTTACTTCCTAAGGCCTCTCATTACTTATCACCTAGCATCATGCTCTTCATA
CATGCCATCTACTTTCAAACGATATACGGCTAACCAGAAAAGTACGGACAATCAGGGACG
AGCAGGGACATGACGCCTTCCGCACAGATCCCAGAGAAAAGCAGGGAAACAAGAAAATAA
GAAAACAAGAAAAACAGTAGTTACCCTTGTAAGTGTCATCCACAACAGAACCAATACTCT
TACTCTTCCGCTCATTCCCCGCAGAATGATAGAACTATTCTAAATCCCCTTGCCTTGCTT
GGCCTTGACTTGGGTTGGGACTTGGACCTCTAGAACCGATGTGCCTTCAAACATCTTAGC
GAGATAAGAGTCTGCCATTAATGCATCGAGCCAATATCTTGGACTAGTACGAGGTTCACG
TAGCCTTTCTTGCACGGCACCAGCGTCCCACCCCAAGTTCTTTGCTATACTGACCGCCTT
ACACATTTTAGTGTGATTCCAACCCAAAGTAGCTCCTCAAAAAGGGTCACCCGATCGGTG
AATCAATCCGCGGCGCAGAAATGTTCGTAGAGCTCTCGTTTCTTCTAGAACGCTCCCTTG
ATGAAACGAAAATTTCCATCACAATAAAGCTCGCACGCCTTTTTGAAAACCCCAAGCTTT
GCTGTGTCTTCTTGTGAAAAGTTTTGCCCAACGATTATCTATTCTACATATAACCGGGGA
GTTAAGCACATCCTATTGCCCTACATTCTCTCCGCTTACTTCATTGTCTAGAGCTCCTGG
GAAACAAAAGACCGAAAAAGCGAAAACAAAATCAGAACAAGGCTTAAGTACTTTTTCACC
AATTGTAGCAAACATTTAACCACATTTTAGCACACTAGCATATAGCATTGTCCTCTGTTA
TTCGTTTTGCTTTTCTCCTTTAGTGTTACTTTTCCCCCAACGTTACACCATTTTTTGATA
TCAACTAAACTGTATACATTATCTTTCTTCAGGGAGAAGC
Chr coordinates
Chr XV from 171070-180309
