S.cerevisiae - Yeastract

Locus Information

Standard Name	DIS3
Systematic Name	YOL021C
Alias	MTR17, RRP44
Strain	S288c
Description	Exosome core complex catalytic subunit; has both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; role in degradation of tRNAs; similar to E. coli RNase R and to human DIS3, which partially complements dis3-81 heat sensitivity; mutations in Dis3p analogous to human mutations implicated in multiple myeloma impair exosome function; protein abundance increases under to DNA replication stress
External sources	Open in SGD Open in KEGG

Gene Sequence Download FASTA Hide Seq	>DIS3 YOL021C ATGTCAGTTCCCGCTATCGCCCCCAGACGGAAGAGACTTGCAGATGGTTTAAGCGTCACT CAGAAGGTGTTTGTAAGGTCTCGTAATGGAGGCGCTACCAAGATCGTAAGAGAACACTAT TTAAGATCGGACATCCCATGTCTTTCGAGAAGTTGTACCAAGTGTCCGCAAATTGTCGTC CCCGATGCTCAAAATGAGTTGCCGAAGTTCATCTTGTCAGATTCTCCCTTAGAATTAAGC GCACCCATTGGTAAGCATTACGTCGTCTTGGATACCAACGTGGTGTTACAGGCAATTGAC CTTTTAGAGAATCCGAATTGTTTTTTCGACGTCATTGTCCCCCAGATTGTCCTAGATGAA GTGAGAAACAAGTCATATCCGGTGTACACGAGATTAAGAACTCTATGCAGAGATAGTGAC GATCATAAGAGATTCATCGTGTTTCATAACGAATTTAGTGAACATACTTTTGTGGAAAGG CTTCCAAATGAAACGATTAATGACAGAAACGACAGGGCTATAAGGAAAACCTGTCAATGG TATAGTGAGCACTTGAAACCTTATGACATAAACGTCGTTCTTGTTACCAACGATCGTTTG AATAGAGAAGCTGCCACTAAGGAAGTGGAGTCCAATATAATAACCAAGAGCTTGGTACAG TATATCGAGTTACTACCAAATGCAGACGACATCAGAGACTCTATTCCTCAAATGGATTCT TTTGATAAAGATCTTGAAAGGGACACATTTTCAGATTTCACGTTCCCGGAGTACTATTCT ACAGCAAGAGTAATGGGTGGTTTGAAAAATGGCGTTTTGTACCAGGGCAATATTCAAATA TCAGAGTACAACTTTCTAGAAGGTTCAGTGAGTTTACCAAGATTTTCCAAACCAGTGTTA ATTGTTGGGCAGAAAAACCTAAATAGAGCATTCAACGGTGACCAGGTTATCGTGGAACTG CTACCTCAATCAGAATGGAAGGCACCCTCATCCATTGTCTTGGATTCTGAACATTTCGAC GTTAACGATAACCCCGATATTGAGGCTGGCGATGACGATGACAATAATGAGTCCTCTTCC AATACCACCGTGATTTCCGACAAGCAGCGCAGGCTGCTTGCTAAAGATGCTATGATAGCT CAAAGATCGAAAAAAATTCAGCCCACGGCAAAAGTTGTATATATACAAAGAAGATCCTGG AGACAGTACGTCGGTCAACTAGCACCAAGTTCTGTTGATCCACAAAGCAGTAGTACACAG AATGTCTTCGTTATTTTGATGGACAAATGTCTTCCAAAAGTCAGAATCAGAACAAGGCGT GCTGCTGAATTATTGGATAAGAGGATTGTCATTTCCATTGATTCGTGGCCCACCACTCAT AAATACCCATTAGGTCACTTTGTGAGAGACCTCGGTACAATTGAATCTGCTCAAGCTGAA ACAGAGGCCTTATTGTTGGAGCATGATGTTGAATATAGGCCTTTTTCCAAGAAAGTTCTA GAATGTTTGCCCGCAGAAGGCCACGATTGGAAGGCCCCAACAAAACTGGACGATCCTGAG GCTGTTTCAAAGGATCCATTATTGACAAAAAGAAAGGATCTCAGAGATAAACTTATATGT AGTATCGATCCTCCAGGATGTGTTGATATTGACGATGCCCTACATGCGAAAAAGCTTCCA AACGGTAATTGGGAAGTTGGTGTTCATATTGCTGATGTTACTCACTTCGTTAAACCGGGC ACTGCCCTGGATGCGGAAGGTGCTGCAAGAGGTACTTCTGTATATTTGGTAGACAAACGT ATTGACATGCTGCCCATGCTTCTAGGTACCGACCTGTGTTCTCTAAAACCATACGTTGAT AGATTCGCATTCTCTGTCATTTGGGAATTGGATGATAGTGCTAATATTGTAAATGTTAAT TTTATGAAATCCGTCATCAGATCTAGAGAAGCTTTCTCATACGAACAAGCACAACTGAGA ATTGATGACAAAACCCAAAATGATGAATTAACGATGGGTATGAGGGCTCTCTTGAAATTG TCTGTAAAACTGAAGCAAAAGAGACTAGAGGCAGGTGCCTTGAACTTAGCTTCTCCTGAG GTTAAGGTCCATATGGATAGTGAGACTTCAGATCCAAATGAAGTGGAAATCAAAAAATTA CTGGCGACAAATTCTTTAGTTGAAGAATTTATGTTGTTGGCTAATATATCAGTGGCAAGG AAGATATACGATGCCTTCCCTCAAACGGCGATGCTAAGAAGACACGCAGCTCCGCCATCT ACCAATTTTGAAATCTTAAATGAAATGTTAAACACAAGAAAGAATATGTCAATTTCGTTG GAATCGTCCAAGGCCTTGGCCGATTCTTTAGACAGGTGTGTGGATCCCGAAGATCCATAT TTTAATACATTGGTTCGTATCATGTCGACTCGCTGTATGATGGCAGCCCAATACTTTTAT TCTGGAGCTTATTCTTATCCTGACTTTAGACACTATGGTTTAGCCGTTGATATCTACACA CATTTCACATCACCTATTAGACGTTACTGTGATGTTGTGGCCCATAGACAATTAGCAGGT GCCATTGGGTATGAACCCCTAAGTTTGACTCATCGTGATAAGAATAAAATGGACATGATT TGCAGAAATATCAACAGAAAGCACAGAAACGCCCAATTCGCCGGTAGGGCAAGCATAGAA TACTATGTCGGGCAAGTAATGAGGAATAACGAGTCCACAGAAACTGGATATGTTATTAAG GTATTTAATAATGGTATAGTCGTACTGGTTCCCAAGTTTGGCGTGGAAGGCTTGATAAGA CTGGATAATTTGACTGAGGATCCTAACTCAGCCGCTTTTGATGAGGTGGAATACAAATTA ACCTTTGTGCCTACAAATTCAGATAAACCGAGGGATGTTTACGTTTTCGATAAGGTCGAA GTTCAAGTTAGGTCGGTGATGGATCCAATTACTAGCAAGCGTAAGGCAGAATTATTGTTA AAATAG
Promoter Sequence Download FASTA	>DIS3 YOL021C CCTTGGTTTCAGAGTCCTCTTCAAATTACTTGTGTCGAACGAGCCGTCCAGAGGAGACTT GAAAGAATCAACACATCGCTGGAAAATATTCCTCTTGCCGTGTTGGTTGTCATCATCGTG ATGCGATGAGTTTGAATTGTGTGATGAGGATGATGTTAATTGCTTGGATTTGTATTCTAC AAATCCAAAGTTAGATTTTCGCTCCTTCAGCTCCTCATTTGAACGCTTGACAGAAGAAAT AAAGTCTTCGGTCATATGAGAGTGTGTTGCGTAATTTGCTTAGCTTATGTTCTTCAGCTA TTTTTGGGAAATGTCGTGCTCGACGTGTTGAGAAAGTCAGTCACCTCAAAAACTTCACAC TATTTAGATCCGCAATGCTCAGATGTATATACAAACAAATATGAATATATCCTTTTGAAC TGGAGTGAATGGTGGGAAATCTCAAATATTTTCTGAAATAGGACCCACACAAGATATTGA AAGTAAGAGAAAAATTTGTGAAAAACTGCCTACGTACCATTTAACGATACACCCCCACCC GAACAAGGTTAGACTACTACAGCTAAGTATAGGAGAGGTAGATGCAATATCATGGCAGCA AAAGAGCGTTCGAATTTTCACTGTCATTTTGTCATTTAATGCCGTTTCTATTCAGTGACA CATGGCGGAAAAGGAAAAAAAGAAAAGATTTTACCATGCGGCAAAACCGTAAAAAGAAAT ATTTTTAGCGCCGTAGCTTCTTTAGGGTATTTGTTTAGGTTAGTATTTATTTTTATTAGG TCATAATAAACCTAAAATAACTTTTAATTAGGGGTTTATTCTTGATTTAAGCCCTATTTC CGGGTAATTGTTTGCCTTCTTTTCTTTTAGGCATTTTCTCTCATCTCAGAAAAATTTTAA TGTGTGTGCTACTGCAGTACTTCTTAGAGATACATTGTGAGGGACCCATTGATCAAACGA GTTTTATTTATCATACTTGCATCATACAGGCCAAAACAAC
Chr coordinates	Chr XV from 285426-282421